The Cochrane Schizophrenia Group

China; a research superpower, but we could be left in dark

By Rebecca Syed, Research Fellow at King’s College London and an Editor for the CSzG

Over the past 25 years we have seen an explosion in top-level clinical trials in China. But only a tiny proportion of that research is available on the main databases used by doctors and researchers in the UK, Australia and the US. It means we could be missing out on evidence for potential medical breakthroughs.

There have been some high-profile cases in China of dodgy research, such as one poorly conducted trial (that didn’t even have ethical approval), but the Chinese have taken steps to improve research integrity. And we have to recognise research misconduct as a global issue.

I conducted a survey of low to middle-income countries randomised control trials in mental health. These studies are modelled very carefully and considered the gold standard of evidence for medical treatments. The survey involved laboriously hand searching databases in each region and in each language. Pretty dry stuff but as it turns out, very important. In China they increased by more than seven times between 1991 and 2000. Read the rest of this entry »

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Research Data Management drop in clinic for researchers – all welcome

Attachment:  RDMResearchersV1.0

Highfields House, Nottingham University

Highfields House, Nottingham University (Photo credit: Stephen Rees)

Date:  Thursday 16th May 2013
Time:  1:00 to 3:00pm
Venue:  Seminar room A.02, Highfield House, University Park, The University of Nottingham Read the rest of this entry »

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Old side effects and old drugs; old side effects and new drugs

silence the voices - still the visions

silence the voices – still the visions (Photo credit: Jackal1)

By Clive Adams

People using antipsychotic drugs like chlorpromazine and haloperidol get [anticholinergic] side effects such as blurred vision, dry mouth and constipation but the proportion of people experiencing these is not clear.

Past surveys are very old indeed, small and not really proper surveys at all. Their results had been perpetuated for decades without verification. They were undertaken so long ago that they were only about older drugs – so the lack of verification had resulted in bias as the older drugs held their reputation of causing these effects and the newer ones never gathered it in the same way. Read the rest of this entry »

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